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Microrna-221/222 confers tamoxifen resistance in breast cancer by targeting p27kip1
15 Aug 2008 … MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting
p27Kip1. Miller TE(1), Ghoshal K, Ramaswamy B, Roy S, Datta J, …MicroRNA-221/222 Confers Tamoxifen Resistance in Breast Cancer by … the cell
cycle inhibitor p27Kip1, a known target of miR-221/222, was reduced by 50% …8 Nov 2010 … MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating ….
However, acquired resistance to both tamoxifen and AI typically …. and
Supplementary Figure S2) further suggested that targeting p27Kip1 may …15 Aug 2008 … MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting
p27(Kip1). Tyler E. Miller1, Kalpana Ghoshal1,3, Bhuvaneswari …17 Jun 2008 … MicroRNA-221/222 Confers Tamoxifen Resistance in Breast. Cancer by
Targeting p27. Kip1*□S. Received for publication … tamoxifen. The protein level
of the cell cycle inhibitor p27Kip1, a known target of miR-221/222, was …15 Oct 2013 … MiR-221/-222 are frequently overexpressed in breast cancer and are … that such
targeting negatively correlates with its expression in breast cancer … BMF or p27
Kip1 (le Sage et al, 2007; Gramantieri et al, 2009; Zhang et al, 2010). ……
MicroRNA-221/222 confers tamoxifen resistance in breast cancer by …16 Feb 2017 … Increased tamoxifen resistance in breast cancer is associated with the inhibition
of p27 … Inhibition of miRNA-221/222 in ER-positive human breast ….. of human
prostate carcinoma cell lines by targeting p27Kip1. …. High level of miR-221/222
confers increased cell invasion and poor prognosis in glioma.15 Nov 2013 … showed that 73% of miRNA genes in breast cancer reside in … tein (BRCP) was
shown to confer tamoxifen resistance (11). In addition ….. p27Kip1 (72) and ERa (
73). … that miR-221, -222, and -181b target TIMP3 directly, with.17 Jun 2013 … Role of miRNAs in the endocrine resistance of breast cancer ….. 1B (p27Kip1)
cell cycle inhibitor, a known target of miRNA-221/222, was reduced by 50% …..
confers tamoxifen resistance in breast cancer by targeting p27Kip1.31 Aug 2011 … MicroRNAs (miRNAs) are crucial in the initiation and progression of tumors. …
roles of miR-221/222 in breast cancer metastasis, drug resistance and RAS …
confers tamoxifen resistance in breast cancer by targeting p27Kip1.Upon binding the 3′ untranslated region (UTR) of target mRNAs, miRNAs …..
ones, confers tamoxifen resistance by targeting the cell cycle inhibitor p27/Kip1 (
43). ….. MicroRNA-221/222 confers tamoxifen resistance in breast cancer by …2 Apr 2012 … proliferation of breast cancer cells is well characterized and will be the … target
genes such as EBAG9 and TFF1. … (CDK) inhibitors p21waf1 and p27kip1 are …
models confers resistance to tamoxifen. ….. MicroRNA-221/222…. to tamoxifen resistance in breast cancer, miR-221/222 expression is ……
confers tamoxifen resistance in breast cancer by targeting p27(Kip1). J Biol
Chem …resistance of breast cancer cells has never been investigated, although its is very
well known to influence invasion … to tamoxifen. Luciferase assays identified
HDAC4 as a direct target of miR-10b. ….. regulation of tumor suppressors
p27Kip1 [6, 38] and …. MicroRNA-221/222 confers tamoxifen resistance in breast
cancer by.13 Dec 2016 … They can negatively modulate target gene expressions through decreasing ….
the p27Kip1 tumor suppressor by miR‐221 and miR‐222 promotes cancer … “
MicroRNA-221/222 confers tamoxifen resistance in breast cancer by …29 Jun 2010 … 3A) with a concomitant up-regulation of its direct target p27Kip1 (Fig. …..
MicroRNA-221/222 confers tamoxifen resistance in breast cancer by …Recent evidences suggest that miRNA/transcript target interaction can also occur
in the … It was subsequently demonstrated that the tumor suppressor p27(Kip1),
which displays reduced … MiR-221/222 is upregulated in HER2-positive primary
human breast cancer tissues and has been linked with tamoxifen resistance .Altered microRNA expression in breast cancer cell lines is associated with
altered ….. the miR-221/222 cluster, and the let-7 and miR-34 families, can
regulate cell cycle …… confers tamoxifen resistance in breast cancer by targeting
p27Kip1.Miller T.E.; et al. MicroRNA-221/222 confers tamoxifen resistance in breast
cancer by targeting p27Kip1. J. Biol. Chem. 2008; 283: 29897-29903. View in
Article.5 Feb 2016 … Keywords: Breast cancerEndocrine resistanceGrowth factor … gene regulators,
exhibit differential expression in tamoxifen-sensitive versus resistant cell lines. …
in the ligand-binding domain may confer endocrine resistance [17,18] and this
may ….. miRNA-221/222 can target and suppress the expression of …
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